- Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers.
- new model of cancer etiology that accounts for these actions of 25(OH)D and calcium.
- Its seven phases are disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition (abbreviated DINOMIT).
- Vitamin D metabolites prevent disjunction of cells(Upregulates E-Cadherins,Catenins and intercellular junctions) and are beneficial in other phases.
- It is projected that raising the minimum year- round serum 25(OH)D level to 40 to 60 ng/mL (100–150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year
- Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half.
- There are no unreasonable risks from intake of 2000 IU per day of vitamin D3, or from a population serum 25(OH)D level of 40 to 60 ng/mL.
Ref- Ann Epidemiol. 2009 Jul 1;19(7):468-483, CF Garland, ED Gorham, AR Mohr, FC Garland