Leukocyte Alkaline Phosphatase levels- Clinical significance.

Leukocyte Alkaline Phosphatase-

• enzyme found in all tissues
• located in neutrophils, involved in intracellular metabolism
• important in distinguishing between chronic granulocytic leukemia and leukemoid (leukemia-like) reactions

Decreased levels-

• nephrotic syndrome
• chronic granulocytic leukemia
• infectious mononucleosis
• paroxysmal nocturnal hemoglobinuria
• chronic myelogenous leukemia
• thrombocytopenic purpura
• sickle cell anemia.

Elevated levels-

• polycythemic vera                                                                                                                                                                             
• leukemoid reactions                                                                                                                                                                         
• myelofibrosis
• Hodgkin's disease
• aplastic leukemia
• thrombocytopenia
• multiple myeloma.

Posted via web from Inquisitives' posterous